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Chemical Structure : GDC-0623
CAS No.: 1168091-68-6
Catalog No.: PC-73145Not For Human Use, Lab Use Only.
GDC-0623 (RG 7421) is a potent, selective, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $728 | In stock | |
| 1 g | Get quote |
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GDC-0623 (RG 7421) is a potent, selective, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM).
GDC-0623 displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM), prevents MEK phosphorylation by CRAF in vitro, and able to block MEK phosphorylation by BRAF(V600E).
GDC-0623 (RG 7421) (40 mg/kg, p.o.) shows percent tumour growth inhibition (%TGI) in MiaPaCa-2 xenograft model.
| M.Wt | 456.21 | |
| Formula | C16H14FIN4O3 | |
| Appearance | Solid | |
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1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.
2. Robarge KD, et al. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4714-4723.
3. Zaanan A, et al. J Biol Chem. 2015 Sep 25;290(39):23838-49.
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