You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-GDC-0927
GDC-0927

Chemical Structure : GDC-0927

CAS No.: 1642297-01-5

GDC-0927 (GDC0927;SRN-927;RG-6047)

Catalog No.: PC-63294Not For Human Use, Lab Use Only.

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with IC50 of 0.1 nM (ER-α degradation) and Emax=97%.

Packing Price Stock Quantity
5 mg $458 In stock
10 mg $758 In stock
25 mg $1280 In stock
100 mg Get quote
200 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with IC50 of 0.1 nM (ER-α degradation) and Emax=97%.
GDC-0927 exhibits IC50 value of 0.1 nM in MCF-7 proliferation assays.
GDC-0927 (100 mg/kg, po) demonstrated tumor regression, together with robust reduction intratumoral ER-α levels in tamoxifen-resistant breast cancer xenograft models.

Physicochemical Properties

M.Wt 461.533
Formula C28H28FNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

References

1. Kahraman M, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):50-55.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: