GH501

Chemical Structure : GH501

Catalog No.: PC-24401Not For Human Use, Lab Use Only.

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Biological Activity

GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF).
GH501 affects multiple oncogenic signals in mCRPC cells, affects multiple oncogenic signals implicated in mCRPC progression, including p21, p27, β-catenin, cyclin D1, enhancer of zeste homolog 2 (EZH2), c-Myc, and survivin.
GH501 monotherapy inhibits the in vivo growth of mCRPC in multiple xenograft models.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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GH501

Biological Activity

Physicochemical Properties

References

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