GHP-88310 (EIDD-3608) is an orally efficacious, non-nucleoside, broad-spectrum orthoparamyxovirus RNA-dependent RNA polymerase (RdRP) inhibitor, shows broad-spectrum antiviral activities for HPIV3, Sendai virus (SeV), MeV, and related canine distemper virus (CDV) with EC50 of 0.53 uM, 1.03 uM and 1.71 uM respectively.
GHP-88310 shows submicromolar activity against orthoparamyxoviruses of the respirovirus [HPIV1, HPIV3, and Sendai virus (SeV)], morbillivirus [MeV and canine distemper virus (CDV)], and henipavirus (Ghana henipavirus and Cedar virus) genera.
GHP-88310 prevents initiation of the viral RdRP complex at the promoter, most likely by sterically blocking structural reorganization of the polymerase from initiation into elongation configuration.
GHP-88310 lowers the respiratory tract viral load in HPIV3-infected cotton rats.
GHP-88310 causes complete survival, reduction of viremia and shed viral load, and alleviated lymphocytopenia in ferrets infected with CDV.
GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease/