Chemical Structure : GI 254023X
CAS No.: 260264-93-5
Catalog No.: PC-73195Not For Human Use, Lab Use Only.
GI 254023X is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
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GI 254023X is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
GI 254023X displays >100-fold selectivity for ADAM10 over ADAM17 (TACE).
GI 254023X bolcks antibody-induced shedding of target antigens, increases specificity of targeted immunotherapy in vitro.
GI 254023X inhibits PACAP-induced shedding of RAGE in PAC1/RAGE cells.
GI 254023X remarkably inhibits the proliferation and induce the apoptosis of H929 cells.
M.Wt | 391.51 | |
Formula | C21H33N3O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
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1. Hundhausen C, et al. Blood. 2003 Aug 15;102(4):1186-95.
2. Budagian V, et al. J Biol Chem. 2004 Sep 24;279(39):40368-75.
3. Verena V Metz, et al. PLoS One
.2012;7(7):e41823.
4. Eichenauer DA, et al. Cancer Res. 2007 Jan 1;67(1):332-8.
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