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GKM-001

Chemical Structure : GKM-001

CAS No.: 1092375-28-4

GKM-001 (GKM001)

Catalog No.: PC-49837Not For Human Use, Lab Use Only.

GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA), demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA) with EC50 of 1.55 and 4.3 uM for human and rat GK, respectively. demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

Physicochemical Properties

M.Wt 580.02
Formula C25H20ClF2N3O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(5-chloro-2-(1-(3,4-difluorobenzyl)-4-(4-(methylsulfonyl)benzyl)-1H-pyrrole-2-carboxamido)thiazol-4-yl)acetic acid

References

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