Chemical Structure : GL-V9
CAS No.:
1178583-19-1
GL-V9
Catalog No.: PC-24392Not For Human Use, Lab Use Only.
GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway.
GL-V9 induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells.
GL-V9 significantly suppressed the expression and activity of MMP-2 and MMP-9.
GL-V9 ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.
GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.
Physicochemical Properties
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M.Wt
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409.48
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Formula
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C24H27NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4H-1-Benzopyran-4-one, 5-hydroxy-8-methoxy-2-phenyl-7-[4-(1-pyrrolidinyl)butoxy]-
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References
1. Li L, et al. Eur J Pharm Sci. 2011 Aug 17;43(5):393-9.
2. Zhao Y, et al. Oncotarget. 2015 Sep 22;6(28):26291-307.
3. Liu H, et al. Pharmaceuticals (Basel). 2024 Oct 10;17(10):1352.
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