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GLPG-2222

Chemical Structure : GLPG-2222

CAS No.: 1918143-53-9

GLPG-2222 (ABBV-2222;ABBV2222;GLPG2222)

Catalog No.: PC-60231Not For Human Use, Lab Use Only.

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
GLPG-2222 is highly potent (5 nM) and efficacious in cells from multiple CF patient donors that have F508del homozygous mutation.
GLPG-2222 shows potential in clinical trials in patients harboring the F508del CFTR mutation on at least one allele.

Physicochemical Properties

M.Wt 559.47
Formula C28H21F4NO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid

References

1. Wang X, et al. J Med Chem. 2017 Dec 18. doi: 10.1021/acs.jmedchem.7b01339.

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