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GLPG2451

Chemical Structure : GLPG2451

CAS No.: 2055015-61-5

GLPG2451 (GLPG 2451)

Catalog No.: PC-49187Not For Human Use, Lab Use Only.

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
GLPG2451 improves the gating function of the CFTR channel.

Physicochemical Properties

M.Wt 419.375
Formula C16H16F3N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-amino-N-(2-hydroxypropyl)-5-((4-(trifluoromethoxy)phenyl)sulfonyl)picolinamide

References

1. Gees M, et al. Front Pharmacol. 2018 Oct 26;9:1221.

2. Van der Plas SE, et al. J Med Chem. 2021 Jan 14;64(1):343-353.

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