Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GLS4
CAS No.: 1092970-12-1
Catalog No.: PC-63326Not For Human Use, Lab Use Only.
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $378 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | $1480 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM).
GLS4 (Morphothiadin) reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations.
GLS4 (Morphothiadin) strongly inhibits core gene expression (at 100 to 200 nM), suppresses virus accumulation in the supernantant of HepAD38 cells.
GLS4 (Morphothiadin) inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice.
| M.Wt | 509.394 | |
| Formula | C21H22BrFN4O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 100 mg/mL |
|
| Chemical Name/SMILES |
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate |
|
1. Wang XY, et al. Antivir Ther. 2012;17(5):793-803.
2. Wu G, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54.
3. Ren Q, et al. Bioorg Med Chem. 2017 Feb 1;25(3):1042-1056.
4. Tu T, et al. J Virol. 2018 Feb 7. pii: JVI.02007-17.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
