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Chemical Structure : GNE-149
Catalog No.: PC-20524Not For Human Use, Lab Use Only.
GNE-149 (GNE149) is a potent, full estrogen receptor alpha (ERα) antagonist and degrader with IC50 of 0.053 nM (MCF7, ERα degradation).
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GNE-149 (GNE149) is a potent, full estrogen receptor alpha (ERα) antagonist and degrader with IC50 of 0.053 nM (MCF7, ERα degradation).
GNE-149 exhibits IC50 value of 0.66 nM and 0.69 nM in MCF-7 and T47D proliferation assays.
GNE-149 (0.3-30 mg/kg) showed dose-dependent efficacy in MCF7 xenograft mouse model harboring either wild-type (WT) ERα or overexpressed Y537S mutant
| M.Wt | 503.59 | |
| Formula | C28H33F4N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang J, et al. ACS Med Chem Lett. 2020 May 26;11(6):1342-1347.
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