GNE-220 (GNE220, GNE 220)

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Chemical Structure : GNE-220

Catalog No.: PC-62936Not For Human Use, Lab Use Only.

GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
GNE-220 alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions。
GNE-220 dose-dependently increases the number of β1-integrin in long focal adhesions.

Physicochemical Properties

M.Wt	438.539
Formula	C25H26N8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine

References

1. Vitorino P, et al. Nature. 2015 Mar 26;519(7544):425-30.

2. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. eCollection 2016.

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