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Chemical Structure : GNE-293
Catalog No.: PC-62886Not For Human Use, Lab Use Only.
GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively.
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GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively。
GNE-293 exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM)。
GNE-293 possesses favorable pharmacokinetic properties and orally bioavailable.
| M.Wt | 580.708 | |
| Formula | C28H36N8O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Safina BS, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9.
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