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Chemical Structure : GNE-317
CAS No.: 1394076-92-6
Catalog No.: PC-43188Not For Human Use, Lab Use Only.
GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP.
GNE-317 inhibits the cell proliferation of GBM6, 10, 22, and 84 with IC50 of 0.59, 0.72, 0.26, and 3.49 uM, respectively.
GNE-317 markedly inhibits the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals.
GNE-317 significantly inhibits tumor growth in orthotopic models of glioblastoma multiforme (GBM).
| M.Wt | 414.4814 | |
| Formula | C19H22N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 20 mg/mL |
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| Chemical Name/SMILES |
2-Pyrimidinamine, 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]- |
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1. Salphati L, et al. Clin Cancer Res. 2012 Nov 15;18(22):6239-48.
2. Lewis Phillips GD, et al. Breast Cancer Res Treat. 2017 Aug;164(3):581-591.
3. Becker CM, et al. Neuro Oncol. 2015 Sep;17(9):1210-9.
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