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Chemical Structure : GNE-3500
Catalog No.: PC-60453Not For Human Use, Lab Use Only.
GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays.
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GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays.
GNE-3500 displays 75-fold selectivity over other ROR family members and >200-fold selectivity over 25 additional nuclear receptors.
GNE-3500 inhibits the production of all three IL-17 subtypes in murine CD4+ T cells with EC50 of 0.27-1.8 uM, also inhibits the production of IL-17AA and -AF by ILCs.
GNE-3500 shows in vitro ADME properties, in vivo PK, and dose-dependent inhibition of IL-17 in vivo.
| M.Wt | 459.58 | |
| Formula | C24H30FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fauber BP, et al. J Med Chem. 2015 Jul 9;58(13):5308-22.
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