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Chemical Structure : GNE-490
CAS No.: 1033739-92-2
Catalog No.: PC-63013Not For Human Use, Lab Use Only.
GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ。
GNE-490 shows >200-fold selectivity over mTOR (IC50=740 nM)。
GNE-490 has good PK profiles, and are efficacious in xenograft models.
| M.Wt | 386.474 | |
| Formula | C18H22N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-Amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol |
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1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.
2. Sampath D, et al. Neoplasia. 2013 Jul;15(7):694-711.
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