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Chemical Structure : GNE-493
CAS No.: 1033735-94-2
Catalog No.: PC-42708Not For Human Use, Lab Use Only.
GNE-493 (GNE493) is a potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-493 (GNE493) is a potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
GNE-493 (GNE493) displays 100-fold selective for PI3Kα over Aurora A, MLK1, Syk.
GNE-493 (GNE493) has good PK profiles, and are efficacious in xenograft models; orally available.
| M.Wt | 372.4447 | |
| Formula | C17H20N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)- |
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1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.
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