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Chemical Structure : GNE-495
CAS No.: 1449277-10-4
Catalog No.: PC-42105Not For Human Use, Lab Use Only.
GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
GNE-495 exhibits adequate potency preventing migration of HUVEC cells in vitro (IC50=57 nM).
GNE-495 has good PK and demonstrates in vivo efficacy in a retinal angiogenesis model .
| M.Wt | 405.4249 | |
| Formula | C22H20FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)- |
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1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.
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