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Chemical Structure : GNE-6468
CAS No.: 1677668-27-7
Catalog No.: PC-35557Not For Human Use, Lab Use Only.
GNE-6468 (GNE6468) is a potent and selective RORc (RORγ) inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ.
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|---|---|---|---|
| 5 mg | $348 | In stock | |
| 10 mg | $528 | In stock | |
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| 100 mg | Get quote |
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GNE-6468 (GNE6468) is a potent and selective RORc (RORγ) inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ.
GNE-6468 displays excellent selectivity profiles against a panel of other nuclear receptors in Gal4 human transcription assays.
GNE-6468 displays potent inhibition of IL-17 production with EC50 of 30 nM in human PBMC cytokine production assays, without effect on IFNγ production.
GNE-6468 is a chemical biology tool to further explore the role of RORc in human biology.
| M.Wt | 433.85 | |
| Formula | C23H16ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl)-2-hydroxybenzoic acid |
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1. Fauber BP, et al. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.
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