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Chemical Structure : GNF-6231
CAS No.: 1243245-18-2
Catalog No.: PC-42139Not For Human Use, Lab Use Only.
GNF-6231 (GNF6231) is a potent, selective and orally bioavailable Porcupine (PORCN) inhibitor with IC50 of 0.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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GNF-6231 (GNF6231) is a potent, selective and orally bioavailable Porcupine (PORCN) inhibitor with IC50 of 0.8 nM.
GNF-6231 has no appreciable activities for more than 200 off-targets, and IC50 of >10 uM against all CYP isoforms.
GNF-6231 reduces Axin2 mRNA levels and inhibits Wnt secretion and pathway activation, induces robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model.
| M.Wt | 448.4927 | |
| Formula | C24H25FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
[2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl- |
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1. Cheng D,, et al. ACS Med Chem Lett. 2016 May 10;7(7):676-80.
2. Bastakoty D, et al. Cell Stem Cells Regen Med. 2016 Nov;2(2).
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