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GNF179

Chemical Structure : GNF179

CAS No.: 1261114-01-5

GNF179 (KAF179)

Catalog No.: PC-47013Not For Human Use, Lab Use Only.

GNF179 is an antimalarial imidazolopiperazine, possesses low nanomolar potency against P. falciparum liver stages, asexual blood stages and sexual stage gametocytes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNF179 is an antimalarial imidazolopiperazine, possesses low nanomolar potency against P. falciparum liver stages, asexual blood stages and sexual stage gametocytes.

Physicochemical Properties

M.Wt 427.908
Formula C22H23ClFN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one

References

1. Meister S, et al. Science. 2011 Dec 9;334(6061):1372-7.

2. Lim MY, et al. Nat Microbiol. 2016 Sep 19;1:16166.

3. Magistrado PA, et al. ACS Infect Dis. 2016 Nov 11;2(11):816-826.

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