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Chemical Structure : GPA 512
Catalog No.: PC-61139Not For Human Use, Lab Use Only.
GPA512 is the orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
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GPA512 is the orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
GPA512 increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone.
GPA512 significantly reduces tumor growth in DU145 xenograft tumors.
| M.Wt | 371.448 | |
| Formula | C17H25NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62.
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