GPR17 antagonist compound 978 | GPR17 antagonist

Chemical Structure : GPR17 antagonist compound 978

GPR17 antagonist compound 978 (NCGC00423978)

Catalog No.: PC-24719Not For Human Use, Lab Use Only.

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Biological Activity

GPR17 antagonist compound 978 (NCGC00423978) is a selective GPR17 antagonistwith IC50 of 6.6 μM, 2.3 μM and 6.1 μM in β-arrestin recruitment, calcium mobilization and cAMP accumulation assays, respectively.
Compound 978 attenuated GPR17 signaling and promoted gut hormone, glucagon-like peptide-1 (GLP-1), secretion in enteroendocrine cells.

Physicochemical Properties

M.Wt	384.86
Formula	C21H21ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(8-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-3,4-dimethoxybenzamide

References

1. Zhu H, et al. Eur J Med Chem. 2025 May 22;295:117794.

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GPR17 antagonist compound 978 (NCGC00423978)

Biological Activity

Physicochemical Properties

References

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