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Chemical Structure : GPR183 antagonist SAE-14
CAS No.: 1241280-25-0
Catalog No.: PC-72117Not For Human Use, Lab Use Only.
GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.
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GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.
GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).
GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.
7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner.
| M.Wt | 364.368 | |
| Formula | C19H19F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3,4-difluorophenyl)-N-(3-fluoro-5-morpholinophenyl)propanamide |
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1. Kathryn Braden, et al. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375.
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