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Chemical Structure : GPR84 antagonist 837
Catalog No.: PC-72357Not For Human Use, Lab Use Only.
Compound 837 (GPR84 antagonist) is a highly potent (affinity, 1 nM), selective antagonist of both orthosteric and allosteric activators of GPR84.
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Compound 837 (GPR84 antagonist) is a highly potent (affinity, 1 nM), selective antagonist of both orthosteric and allosteric activators of GPR84.
Compound 837 is able to fully block activation of human GPR84 promoted by each of 2-HTP and 6-OAU in [35S]GTPγS binding assays.
Compound 837also fully reversed activation of human GPR84 produced by 3,3′-diindolylmethane (DIM), also forskolin-amplified cAMP levels produced by both 2-HTP and 6-OAU.
| M.Wt | 422.488 | |
| Formula | C26H22N4O2 | |
| Appearance | Solid | |
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1. Laura Jenkins, eta l. ACS Pharmacol Transl Sci. 2021 Sep 7;4(5):1598-1613.
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