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Chemical Structure : GQ-16
Catalog No.: PC-49036Not For Human Use, Lab Use Only.
GQ-16 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand and partial agonist with Ki value of 160 nM, specific for PPARγ with no detectable activity to activate other PPAR subtypes (PPARα or PPARβ/δ) or RXRα.
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GQ-16 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand and partial agonist with Ki value of 160 nM, specific for PPARγ with no detectable activity to activate other PPAR subtypes (PPARα or PPARβ/δ) or RXRα.
GQ-16 elicited only approximately one-third of the maximal activation stimulated by rosiglitazone at high concentrations.
GQ-16 is significantly less effective in promoting the interaction between PPARγ and SRC-1 than the TZD troglitazone in in vitro binding studies.
GQ-16 displayed reduced adipogenic potential in both NIH-3T3 and C3H10T1/2 cells, established models of PPARγ-dependent adipogenesis.
GQ-16 improves insulin-signaling components in liver, muscle, and adipose tissue of obese Swiss mice.
GQ-16 improves insulin sensitivity without evoking weight gain and inhibits Cdk5 phosphorylation of PPARγ in vitro.
| M.Wt | 418.305 | |
| Formula | C19H16BrNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Amato AA, et al. J Biol Chem. 2012 Aug 10;287(33):28169-79.
2. Coelho MS, et al. PLoS One. 2016 May 3;11(5):e0154310.
3. da Costa Leite L. F.,et al. Eur. J. Med. Chem. 42, 1263–1271
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