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Chemical Structure : GRL018-21
Catalog No.: PC-21461Not For Human Use, Lab Use Only.
GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.
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GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.
GRL018-21 forms a hemithioketal intermediate with active site Cys474 in the GRK5 active site.
| M.Wt | 526.52 | |
| Formula | C29H23FN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yueyi Chen, et al. Eur J Med Chem. 2023 Nov 10:264:115931.
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