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Chemical Structure : GRN-529
Catalog No.: PC-61060Not For Human Use, Lab Use Only.
A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM.
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A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM; displays >1,000-fold selective vs mGluR1; reduces repetitive behaviors and rescues social deficits in mouse models of autism, demonstrates dose-dependent efficacy across a therapeutically relevant battery of animal models, comprising depression, anxiety and pain, with no effect on rat sexual behavior or motor co-ordination.
| M.Wt | 391.378 | |
| Formula | C22H15F2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Silverman JL, et al. Sci Transl Med. 2012 Apr 25;4(131):131ra51.
2. Hughes ZA, et al. Neuropharmacology. 2013 Mar;66:202-14.
3. Harvey BD, et al. Neuropharmacology. 2013 Dec;75:19-30.
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