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Chemical Structure : GS-8873
Catalog No.: PC-22186Not For Human Use, Lab Use Only.
GS-8873 is a potent, orally bioavailable inhibitor of HBV surface antigen (HBsAg) with EC50 of 4 nM in HepG2-NTCP assays, via inhibition of the human poly(A) polymerases PAPD5/7, promoting destabilization and degradation of HBV mRNA.
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GS-8873 is a potent, orally bioavailable inhibitor of HBV surface antigen (HBsAg) with EC50 of 4 nM in HepG2-NTCP assays, via inhibition of the human poly(A) polymerases PAPD5/7, promoting destabilization and degradation of HBV mRNA.
GS-8873 exhibits excellent cellular activity and preclinical pharmacokinetic parameters superior to RG7834.
GS-8873 was shown to cause neuroelectrophysiology deficits in rats and monkeys, leading to its discontinuation.
| M.Wt | 442.51 | |
| Formula | C24H30N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kato D, et al. ACS Med Chem Lett. 2024 Mar 22;15(4):546-554.
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