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Chemical Structure : GSK-2292767
Catalog No.: PC-70090Not For Human Use, Lab Use Only.
GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).
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GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).
GSK-2292767 displays >1,000 fold selectivity versus others PI3K isoforms.
GSK-2292767 inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.7 and 8.5, respectively, in a human lung parenchyma assay.
GSK-2292767 shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=35 ug/kg).
| M.Wt | 512.58 | |
| Formula | C24H28N6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.
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