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Chemical Structure : GSK-229423
Catalog No.: PC-61940Not For Human Use, Lab Use Only.
GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
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GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
GSK-229423 displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101.
GSK-229423 has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
| M.Wt | 459.612 | |
| Formula | C26H29N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.
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