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GSK-229423

Chemical Structure : GSK-229423

CAS No.: 1352149-24-6

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GSK-229423 (GSK229423)

Catalog No.: PC-61940Not For Human Use, Lab Use Only.

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
    GSK-229423 displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101.
    GSK-229423 has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.

    Physicochemical Properties

    M.Wt 459.612
    Formula C26H29N5OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-ethylquinoline-3-carbonitrile

    References

    1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.

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