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Chemical Structure : GSK-729
Catalog No.: PC-61004Not For Human Use, Lab Use Only.
A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
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A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3; selectively pulls down EchA6 in a stereospecific manner in M. bovis BCG extracts, competes with CoA-binding, suppresses mycolic acid synthesis, and are bactericidal in mouse model of chronic tuberculosis infection.
| M.Wt | 339.318 | |
| Formula | C16H16F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.
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