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Chemical Structure : GSK-843
CAS No.: 1601496-05-2
Catalog No.: PC-38490Not For Human Use, Lab Use Only.
GSK-843 (GSK'843) is a specific small molecule receptor-interacting protein kinase 3 (RIPK3) inhibitor, binds to RIP3 kinase domain with high affinity (IC50=8.6 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $148 | In stock | |
| 5 mg | $238 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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GSK-843 (GSK'843) is a specific small molecule receptor-interacting protein kinase 3 (RIPK3) inhibitor, binds to RIP3 kinase domain with high affinity (IC50=8.6 nM).
GSK-843 (GSK'843) does not inhibit RIP1 kinase (RIPK1), and a panel of 300 human protein kinases.
GSK-843 (GSK'843) blocked TNF-induced necroptosis in a concentration-dependent manner in primary human neutrophils isolated from whole blood.
GSK-843 (GSK'843) inhibited TLR3- or DAI-induced death, two RIP1-independent pathways of necroptosis.
GSK-843 (GSK'843) induced caspase activation followed by apoptotic cell death in different cell types.
| M.Wt | 377.484 | |
| Formula | C19H15N5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Benzothiazol-5-yl-7-(2,5-dimethyl-2H-pyrazol-3-yl)-thieno[3,2-c]pyridin-4-ylamine |
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1. Mandal P, et al. Mol Cell. 2014 Nov 20;56(4):481-95.
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