Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GSK-8999
Catalog No.: PC-62831Not For Human Use, Lab Use Only.
GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively.
GSK-8999 shows high potency against 57 of 62 isolates demonstrating an improvement over the first generation maturation inhibitor BVM.
GSK-8999 has a mechanism of action consistent with inhibition of the proteolytic cleavage of CA-SP1.
| M.Wt | 776.44 | |
| Formula | C46H62ClNO7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Tang J, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2689-2694.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
