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Chemical Structure : GSK0660
CAS No.: 1014691-61-2
Catalog No.: PC-43009Not For Human Use, Lab Use Only.
GSK0660 is a potent, selective, dual PPARβ/δ antagonist with pIC50 of 6.8 (160 nM), shows no activity on PPARα and PPARγ (IC50>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $528 | In stock |
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GSK0660 is a potent, selective, dual PPARβ/δ antagonist with pIC50 of 6.8 (160 nM), shows no activity on PPARα and PPARγ (IC50>10 uM); antagonizes 100% of the activity of PPARβ/δ with a pIC50 of 6.53, reduces CPT1a expression in skeletal muscle cells with EC50 of 100 nM, as well as ANGPTL4 but not PDK4; significantly reduces inhibitory effect of GW501516 on the LPS-induced expression of gp91phox mRNA in BV-2 cells.
| M.Wt | 418.4866 | |
| Formula | C19H18N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester |
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1. Shearer BG, et al. Mol Endocrinol. 2008 Feb;22(2):523-9.
2. Jiménez R, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):554-61.
3. Riahi Y, et al. Diabetes. 2010 Apr;59(4):808-18.
4. Lee WJ, et al. J Cell Biochem. 2018 Feb 1. doi: 10.1002/jcb.26732.
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