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Chemical Structure : GSK1059615
CAS No.: 958852-01-2
Catalog No.: PC-42850Not For Human Use, Lab Use Only.
GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively.
GSK1059615 inhibits survival and proliferation of established (SCC-9, SQ20B and A253 lines) and primary human HNSCC cells.
GSK1059615 blocks PI3K-AKT-mTOR activation in HNSCC cells, induces programmed necrosis but not apoptosis, suppresses SCC-9 tumor growth in nude mice.
GSK1059615 strongly reduces neutrophil-sperm interaction with IC50 of <10 nM in cattle.
| M.Wt | 333.3638 | |
| Formula | C18H11N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-, (5Z)- |
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1. Carnero A. et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.
2. Xie J, et al. Oncotarget. 2017 Feb 7;8(31):50814-50823.
3. Leontieva OV, et al. Aging (Albany NY). 2016 Dec 30;8(12):3535-3551.
4. Hong J, et al. Biol Reprod. 2017 Nov 1;97(5):671-687.
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