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GSK1292263

Chemical Structure : GSK1292263

CAS No.: 1032823-75-8

GSK1292263 (GSK 1292263;GSK-1292263)

Catalog No.: PC-42879Not For Human Use, Lab Use Only.

GSK1292263 is a novel potent, selective GPR119 agonist, elevates circulating glucose-dependent insulinotropic peptide, GLP-1 and peptide tyrosine-tyrosine in nonclinical models of diabetes, with no effect on plasma glucose..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK1292263 is a novel potent, selective GPR119 agonist, elevates circulating glucose-dependent insulinotropic peptide, GLP-1 and peptide tyrosine-tyrosine in nonclinical models of diabetes, with no effect on plasma glucose.

Dyslipidemia

Phase 2 Discontinued

Physicochemical Properties

M.Wt 456.5578
Formula C23H28N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Pyridine, 5-[[1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methoxy]-2-[4-(methylsulfonyl)phenyl]-

References

1. Polli JW, et al. Xenobiotica. 2013 Jun;43(6):498-508.

2. Nunez DJ, et al. PLoS One. 2014 Apr 3;9(4):e92494.

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