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Chemical Structure : GSK1838705A
CAS No.: 1116235-97-2
Catalog No.: PC-43330Not For Human Use, Lab Use Only.
GSK1838705A is a potent, specific inhibitor of IGF-IR and insulin receptor (IR) with IC50 of 2.0 and 1.6 nM, also is a potent inhibitor of ALK with IC50 of 0.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $768 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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GSK1838705A is a potent, specific inhibitor of IGF-IR and insulin receptor (IR) with IC50 of 2.0 and 1.6 nM, also is a potent inhibitor of ALK with IC50 of 0.5 nM; display excellent kinase selectivity on a panel of 224 unique protein kinases with only 7 additional kinases to be inhibited by >50% at 0.3 uM; inhibits a panel of cell lines derived from solid and hematologic tumors with IC50 of 20 nM-8 uM (NCI-H929 IC50=197 nM); causes complete regression of ALK-dependent tumors, retards the growth of human tumor xenografts in vivo with minimal effects on glucose homeostasis.
| M.Wt | 532.5693 | |
| Formula | C27H29FN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 2-[[2-[[1-[2-(dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methyl- |
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1. Sabbatini P, et al. Mol Cancer Ther. 2009 Oct;8(10):2811-20.
2. Zhou F, et al. Onco Targets Ther. 2015 Apr 10;8:753-60.
3. Refolo MG, et al. Oncotarget. 2017 Sep 30;8(61):103465-103476.
4. Kelleher FC, et al. Eur J Cancer. 2010 Sep;46(13):2357-68.
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