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Chemical Structure : GSK1904529A
CAS No.: 1089283-49-7
Catalog No.: PC-42636Not For Human Use, Lab Use Only.
GSK1904529A is a potent, selective, ATP-competitive inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK1904529A is a potent, selective, ATP-competitive inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM.
GSK1904529A showes poor activity in a panel of 45 other serine/threonine and tyrosine kinases.
GSK1904529A potently inhibits phosphorylation of IGF-IR (IC50=22 nM) and IR (IC50=19 nM).
GSK1904529A decreases the growth of human tumor xenografts in mice; orally active.
| M.Wt | 851.9631 | |
| Formula | C44H47F2N9O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-methoxy- |
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1. Sabbatini P, et al. Clin Cancer Res. 2009 May 1;15(9):3058-67.
2. Zhou Q, et al. Mol Med Rep. 2015 Sep;12(3):3381-5.
3. Fei HD, et al. Oncotarget. 2017 May 16.
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