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Chemical Structure : GSK 2332255B
CAS No.: 1366233-41-1
Catalog No.: PC-70336Not For Human Use, Lab Use Only.
GSK 2332255B (GSK2332255B, GSK255B) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $328 | In stock | |
| 5 mg | $528 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK 2332255B (GSK2332255B, GSK255B) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively.
GSK 2332255B dispalys >100-fold selectivity over other calcium-permeable channels.
GSK 2332255B is 100-fold greater potency for TRPC3 compared with Pyr3.
GSK 2332255B dose-dependent blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
| M.Wt | 411.876 | |
| Formula | C18H19ClFN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-chloro-2-((6-fluorobenzo[d][1,3]dioxol-5-yl)amino)thiazol-4-yl)(2,3-dimethylpiperidin-1-yl)methanone |
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1. Seo K, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6.
2. Washburn DG, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.
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