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Chemical Structure : GSK2798745
CAS No.: 1419609-94-1
Catalog No.: PC-72599Not For Human Use, Lab Use Only.
GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $358 | In stock | |
| 5 mg | $558 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).
GSK2798745 displays excellent TRP selectivity (M5, A1, C3, and C6 >25 uM, and efficacy in an in vivo rat PK/PD model of pulmonary edema.
| M.Wt | 460.538 | |
| Formula | C25H28N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(((5S,7S)-3-(5-(2-Hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile |
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1. Brooks CA, et al. ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.
2. Ludbrook VJ, et al. ERJ Open Res. 2021 Aug 2;7(3):00269-2021.
3. Xu X, et al. J Pharmacol Exp Ther. 2021 Mar;376(3):436-443.
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