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Chemical Structure : GSK 2833503A
Catalog No.: PC-70337Not For Human Use, Lab Use Only.
GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively.
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GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively.
GSK 2833503A dispalys >100-fold selectivity over other calcium-permeable channels.
GSK 2833503A shows 100-fold greater potency for TRPC3 compared with Pyr3.
GSK 2833503A dose-dependent blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
| M.Wt | 381.894 | |
| Formula | C18H21ClFN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seo K, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6.
2. Washburn DG, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.
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