GSK2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM.
GSK2982772 inhibits RIP1-dependent inflammatory cytokine MIP-1β production in human whole blood with IC50 of 0.5 nM.
GSK2982772 reduces spontaneous production of cytokines (IL-1β and IL-6) in a concentration-dependent fashion from ulcerative colitis explant tissue.
GSK2982772 shows potential for the treatment of inflammatory diseases in vivo.
