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Chemical Structure : GSK3395879
Catalog No.: PC-35713Not For Human Use, Lab Use Only.
GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4).
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GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4).
GSK3395879 exhibits little or no activity against a broad panel of TRP channels (IC50 > 10µM for TRPA1, TRPV1, TRPM2, TRPM4, TRPM8, TRPC3, TRPC4, TRPC5, TRPC6).
GSK3395879 demonstrates the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model.
| M.Wt | 485.41 | |
| Formula | C20H15F4N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brnardic EJ, et al. J Med Chem. 2018 Oct 18. doi: 10.1021/acs.jmedchem.8b01317.
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