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Chemical Structure : GSK 356278
Catalog No.: PC-60657Not For Human Use, Lab Use Only.
A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B).
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A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B); equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7, exhibits >100-fold selectivity for PDE4B over the other 10 PDEs; inhibits LPS-induced release of TNF-α in human whole blood with pIC50 of 7.6, demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in models of anxiety.
Anxiety
Phase 1 Clinical
| M.Wt | 439.538 | |
| Formula | C21H25N7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rutter AR, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63.
2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.
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