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Chemical Structure : GSK3640254
Catalog No.: PC-72601Not For Human Use, Lab Use Only.
GSK3640254 (GSK254, Fipravirimat) is a novel potent HIV-1 maturation inhibitor with EC90 of 33 nM against a minilibrary of clinically relevant HIV-1 polymorphisms in a multiple-cycle assay.
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GSK3640254 (GSK254, Fipravirimat) is a novel potent HIV-1 maturation inhibitor with EC90 of 33 nM against a minilibrary of clinically relevant HIV-1 polymorphisms in a multiple-cycle assay.
GSK3640254 shows potent binding affinity for HIV-1 VLPs ( Kd=1.4 nM).
GSK3640254 displayed strong antiviral activity against a library of subtype B and C chimeric viruses containing Gag polymorphisms and site-directed mutants previously shown to affect potency of earlier-generation maturation inhibitors.
GSK3640254 exhibited robust antiviral activity against a panel of HIV-1 clinical isolates in PBMCs with a mean EC50 of 9 nM.
GSK3640254 inhibited cleavage of p25 in a range of polymorphic HIV-1 Gag VLPs.
| M.Wt | 727.077 | |
| Formula | C43H67FN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dicker I, et al. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0187621.
2. Spinner CD, et al. Clin Infect Dis. 2022 Jan 6:ciab1065.
3. Pene Dumitrescu T, et al. Br J Clin Pharmacol. 2021 Aug 24.
4. Pene Dumitrescu T, Antimicrob Agents Chemother. 2021 May 18;65(6):e02173-20.
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