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Chemical Structure : GSK429286A
CAS No.: 864082-47-3
Catalog No.: PC-42776Not For Human Use, Lab Use Only.
A poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $112 | In stock | |
| 25 mg | $192 | In stock | |
| 50 mg | $336 | In stock | |
| 100 mg | Get quote |
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A poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM); inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively; has oral bioavailability.
| M.Wt | 432.3709 | |
| Formula | C21H16F4N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]- |
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1. Goodman KB, et al. J Med Chem. 2007 Jan 11;50(1):6-9.
2. Nichols RJ, et al. Biochem J, 2009, 424(1), 47-60.
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