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Chemical Structure : GSK547
CAS No.: 2226735-55-1
Catalog No.: PC-35793Not For Human Use, Lab Use Only.
GSK547 (RIP1i, GSK'547, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK547 (RIP1i, GSK'547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo.
GSK547 exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963.
GSK547 reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner.
RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA).
| M.Wt | 396.402 | |
| Formula | C20H18F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile |
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1. Wang W, et al. Cancer Cell. 2018 Nov 12;34(5):757-774.e7.
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