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GSK 951A

Chemical Structure : GSK 951A

CAS No.: 1403602-33-4

GSK 951A (GSK951A;GSK-951A)

Catalog No.: PC-61005Not For Human Use, Lab Use Only.

A small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM; suppresses mycolic acid synthesis and EchA6 is essential, and are bactericidal in mouse model of chronic tuberculosis infection.

Physicochemical Properties

M.Wt 472.468
Formula C24H23F3N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

References

1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.

2. Remuiñán MJ, et al. PLoS One. 2013 Apr 17;8(4):e60933.

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