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GSK_WRN1

Chemical Structure : GSK_WRN1

CAS No.: 2324194-06-9

GSK_WRN1 (GSK-WRN1)

Catalog No.: PC-22107Not For Human Use, Lab Use Only.

GSK_WRN1 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 5.8, covalently targets WRN Cys727 residue.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GSK_WRN1 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 5.8, covalently targets WRN Cys727 residue.

Physicochemical Properties

M.Wt 312.33
Formula C17H16N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl (E)-4-(2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxamido)but-2-enoate

References

1. Picco G, et al. Cancer Discov. 2024 Apr 9. doi: 10.1158/2159-8290.CD-24-0052.

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